Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | NME2 | P22392 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11083394 | 1.00 | POLB (0.73) | POLBMEN1KMT2AHPGDKDM4E | |
| SCHEMBL11090290 | 0.94 | POLB (0.64) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11090294 | 0.94 | POLB (0.64) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11084370 | 0.93 | POLB (0.66) | POLBMEN1KMT2AHPGDKDM4E | |
| SCHEMBL11084367 | 0.93 | POLB (0.66) | POLBMEN1KMT2AHPGDKDM4E | |
| SCHEMBL11081100 | 0.86 | POLB (0.57) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11081096 | 0.86 | POLB (0.57) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11081815 | 0.84 | POLB (0.57) | POLBMEN1KMT2AHPGDKDM4E | |
| SCHEMBL11081819 | 0.84 | POLB (0.57) | POLBMEN1KMT2AHPGDKDM4E | |
| SCHEMBL11087361 | 0.83 | POLB (0.75) | POLBMEN1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |