SCHEMBL110840

SCHEMBL110840

Nc1c(Cl)ccc(O)c1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.59
MAPK1 P28482 2/20 0.59
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
TSHR P16473 6/20 0.44
HSD17B10 Q99714 6/20 0.41
ALDH1A1 P00352 5/20 0.41
HPGD P15428 3/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CA12 O43570 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
TDP1 Q9NUW8 1/20 0.39
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
ESR1 P03372 2/20 0.35
ESR2 Q92731 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29356274 1.00 CYP3A4 (0.59) CYP3A4MAPK1CA1CA2TSHR
SCHEMBL4856943 1.00 CYP3A4 (0.59) CYP3A4MAPK1CA1CA2TSHR
Hydrochloric Acid SCHEMBL374537 0.97 CYP3A4 (0.56) CYP3A4MAPK1CA1CA2TSHR
Hydrochloric Acid SCHEMBL30818252 0.97 CYP3A4 (0.56) CYP3A4MAPK1CA1CA2TSHR
Propane SCHEMBL10791092 0.89 MAPK1 (0.48) CYP3A4MAPK1CA1CA2TSHR
Acetic Acid SCHEMBL9775966 0.87 CYP3A4 (0.46) CYP3A4MAPK1CA1CA2TSHR
SCHEMBL10703972 0.81 CA1 (0.48) CYP3A4MAPK1CA1CA2TSHR
SCHEMBL3945285 0.80 CYP3A4 (0.39) CYP3A4MAPK1CA1CA2TSHR
SCHEMBL5009700 0.79 ALOX15 (0.46) CYP3A4MAPK1CA1CA2TSHR
SCHEMBL3919358 0.79 CYP3A4 (0.59) CYP3A4MAPK1CA1CA2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4619 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144724-A1 Mixture of at least five surfactants (I1) to (I5) WELLA GERMANY GMBH (DE) 2026-05-28 US claimed
US-12636241-B1 Method and composition for oxidative hair coloring WELLA OPERATIONS US LLC (US) 2026-05-26 US claimed
US-12622856-B2 Agent for oxidative dyeing of keratin fibers, containing isatin and at least one defined polymer HENKEL AG & CO. KGAA (DE) 2026-05-12 US claimed
EP-4731170-A1 OXIDATIVE HAIR COLOURING COMPOSITION COMPRISING A CHELANT MIXTURE Wella Germany GmbH (DE) 2026-04-29 EP claimed
US-12564545-B2 Hair coloring compositions comprising 2-amino-1-propanol as alkalising agents WELLA GERMANY GMBH (DE) 2026-03-03 US claimed
EP-4608363-A1 A COMPOSITION FOR IMPROVING EFFECTIVENESS OF DYE PRECURSORS FOR CHANGE OF COLOUR OF HAIR Cavinkare Pvt. Ltd (IN) 2025-09-03 EP claimed
US-12383482-B2 Hair coloring compositions WELLA GERMANY GMBH (DE) 2025-08-12 US claimed
US-20250161176-A1 SOLID COMPOSITION FOR DYEING KERATIN KAO CORPORATION (JP) 2025-05-22 US claimed
EP-4552630-A1 RESORCINOL FREE PERMANENT HAIR COLOR COMPOSITION AND METHOD Wella Operations US, LLC (US) 2025-05-14 EP claimed
WO-2025061319-A2 IMPROVING THE WASHING FASTNESS OF LEVEL 2 COLORATIONS BY MEANS OF A SEALING PROCESS USING SILANES HENKEL AG & CO. KGAA (DE) 2025-03-27 WO claimed
EP-0506549-A1 Dyeing composition for keratinous fibers containing oxidation dye precursors and hydroxybenzofurans as couplers and dyeing process making use of such a composition L'OREAL (FR) 1992-09-30 EP claimed
EP-0470099-A1 HAIR COLORANTS. HENKEL KGAA (DE) 1992-02-12 EP claimed
WO-1990012562-A1 HAIR COLORANTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1990-11-01 WO claimed
US-4904275-A OXIDIZER L'OREAL (FR) 1990-02-27 US claimed
US-4842612-A DEVELOPERS USED WITH COUPLERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1989-06-27 US claimed
US-4838893-A AND TETRAAMINOPYRIDINES ASDEVELOPER COMPONENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1989-06-13 US claimed
US-4745652-A DEVELOPERS FOR DYES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1988-05-24 US claimed
US-4394521-A Process for the production of the Schiff's bases of 2,6-dichloro-5-hydroxy-aniline LONZA-WERKE G.M.B.H. (DE) 1983-07-19 US claimed
EP-0039419-A1 Process for preparing 2,6-dichloro-5-hydroxy aniles LONZA-Werke GmbH (DE) 1981-11-11 EP claimed
US-4129414-A Oxidation hair colorants containing water-soluble polyhalogen 3-aminophenols as couplers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1978-12-12 US claimed