Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.46 |
| ▸ | CDC7 | O00311 | 4/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091096 | 0.86 | CYP19A1 (0.42) | CYP19A1CDC7 | |
| SCHEMBL11080028 | 0.81 | PDE3B (0.44) | CYP19A1CDC7PDE3BPDE3ANPC1 | |
| SCHEMBL10762285 | 0.80 | PDE3B (0.60) | CYP19A1PDE3BPDE3AMAPK1 | |
| SCHEMBL11083746 | 0.78 | CYP19A1 (0.39) | CYP19A1CDC7PDE3BPDE3ANPC1 | |
| SCHEMBL11089316 | 0.78 | DDB1 (0.32) | CYP19A1DDB1CRBN | |
| SCHEMBL10764278 | 0.76 | PDE3B (0.46) | CYP19A1PDE3BPDE3A | |
| SCHEMBL11112991 | 0.75 | CYP19A1 (0.44) | CYP19A1CDC7PDE3BPDE3ADDB1 | |
| SCHEMBL11114304 | 0.72 | GAA (0.42) | GRM2DDB1CRBN | |
| SCHEMBL10364522 | 0.71 | PDE3B (0.40) | CYP19A1PDE3BPDE3A | |
| SCHEMBL10761590 | 0.70 | PDE3B (0.57) | CYP19A1PDE3BPDE3AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | disclosed |