Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11083746 | 0.83 | CYP19A1 (0.39) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11088815 | 0.82 | CYP11B1 (0.42) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11128659 | 0.82 | BRD4 (0.44) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11084451 | 0.81 | CYP19A1 (0.46) | PDE3BPDE3ACYP19A1CDC7NPC1 | |
| SCHEMBL11084555 | 0.81 | PDE2A (0.39) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10539855 | 0.80 | PDE3B (0.66) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10761383 | 0.79 | PDE3B (0.73) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL9722411 | 0.78 | GAA (0.41) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10757069 | 0.78 | PDE3B (0.72) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11085569 | 0.77 | DDB1 (0.34) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | claimed |
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | claimed |
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | disclosed |