Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | HSD11B1 | P28845 | 11/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11081075 | 0.98 | MEN1 (0.74) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18390858 | 0.95 | MEN1 (0.69) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11088640 | 0.92 | HSD11B1 (0.73) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2479508 | 0.88 | HSD11B1 (0.79) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6543280 | 0.88 | HSD11B1 (0.79) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6896465 | 0.87 | MEN1 (1.00) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4630666 | 0.86 | HSD11B1 (0.79) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6544495 | 0.86 | HSD11B1 (0.73) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8231613 | 0.85 | HSD11B1 (0.59) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 | |
| Water SCHEMBL6544001 | 0.85 | HSD11B1 (0.77) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017011776-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. (US) | 2017-01-19 | — | — | WO | disclosed |
| US-4426382-A | HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1984-01-17 | — | — | US | disclosed |