Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976574 | 0.93 | CCR8 (0.49) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6976570 | 0.93 | CCR8 (0.49) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6977253 | 0.86 | CCR8 (0.48) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL11079444 | 0.82 | MTNR1A (0.45) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL7081967 | 0.82 | CCR8 (0.47) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6977177 | 0.80 | CCR8 (0.53) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6977174 | 0.80 | CCR8 (0.53) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6977170 | 0.80 | CCR8 (0.53) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6965276 | 0.78 | CCR8 (0.53) | CYP2D6KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL6971729 | 0.77 | CCR8 (0.52) | CYP2D6KCNH2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472403-A | Quinoline derivatives and pharmaceutical compositions and methods for treating cardiovascular disease with such compounds | A.C.F. CHEMIEFARMA N.V. (NL) | 1984-09-18 | — | — | US | disclosed |
| EP-0030044-A1 | Quinoline derivatives, processes for their preparation, their use, pharmaceutical compositions containing them and a method for the preparation of these pharmaceutical compositions | ACF CHEMIEFARMA NV (NL) | 1981-06-10 | — | — | EP | disclosed |