Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089316 | 0.83 | DDB1 (0.32) | DDB1CRBNBRD4CREBBP | |
| SCHEMBL11128659 | 0.82 | BRD4 (0.44) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11080028 | 0.77 | PDE3B (0.44) | DDB1CRBNPDE3BPDE3APDE2A | |
| SCHEMBL11084555 | 0.74 | PDE2A (0.39) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11088815 | 0.73 | CYP11B1 (0.42) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL9722411 | 0.72 | GAA (0.41) | DDB1CRBNPDE3BPDE3APDE2A | |
| SCHEMBL11086423 | 0.71 | GAA (0.43) | DDB1CRBNBRD4CREBBP | |
| SCHEMBL10761383 | 0.67 | PDE3B (0.73) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10761022 | 0.67 | PDE3B (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10757069 | 0.67 | PDE3B (0.72) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | disclosed |