Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12868282 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL11091287 | 0.84 | GAA (0.40) | ALDH1A1MAPTSMN1; SMN2GAAAPOBEC3A | |
| SCHEMBL10127936 | 0.78 | GAA (0.57) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL10127804 | 0.78 | GAA (0.57) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL10127868 | 0.78 | GAA (0.57) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL11089644 | 0.72 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL12868246 | 0.71 | GAA (0.48) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL12882152 | 0.71 | GAA (0.62) | ALDH1A1MAPTGAAAPOBEC3AAPOBEC3G | |
| SCHEMBL11090490 | 0.70 | CYP2D6 (0.36) | MAPTKDM4EMEN1KMT2ASLC6A2 | |
| SCHEMBL8036541 | 0.70 | GAA (0.56) | ALDH1A1MAPTKDM4ESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440768-A | ANTIPSYCHOTIC, ANALGESIC AND ANTIDEPRESSANT AGENTS | ICI AMERICAS INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4350814-A | ANTIPSYCHOTIC, ANALGESIC, ANTIDEPRESSANT | ICI AMERICAS INC. (US) | 1982-09-21 | — | — | US | disclosed |
| US-4268513-A | ANALGESICS, ANTIDEPRESSANTS, ANTIPSYCHOTICS | ICI AMERICAS INC. (US) | 1981-05-19 | — | — | US | disclosed |