Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30179988 | 0.88 | KMT2A (0.48) | ALOX5KMT2AMEN1SMN1; SMN2EPHX1 | |
| SCHEMBL11080465 | 0.82 | USP5 (0.42) | SMN1; SMN2EPHX1 | |
| SCHEMBL11081110 | 0.82 | EPHX1 (0.40) | KMT2AEPHX1 | |
| SCHEMBL11082974 | 0.82 | CYP2C9 (0.42) | KMT2AMEN1EPHX1CYP1A2 | |
| SCHEMBL11080596 | 0.82 | ALOX5 (0.46) | ALOX5SMN1; SMN2EPHX1 | |
| SCHEMBL11073404 | 0.82 | EPHX1 (0.40) | EPHX1 | |
| SCHEMBL11077388 | 0.82 | KMT2A (0.34) | ALOX5KMT2AMEN1SMN1; SMN2EPHX1 | |
| SCHEMBL3353032 | 0.81 | EPHX1 (0.59) | ALOX5KMT2ASMN1; SMN2EPHX1CYP1A2 | |
| SCHEMBL28817047 | 0.81 | EPHX1 (0.45) | ALOX5KMT2AMEN1SMN1; SMN2EPHX1 | |
| SCHEMBL11073709 | 0.80 | PARP1 (0.42) | SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |