Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11082757 | 1.00 | CRBN (0.35) | CRBNPDE3APDE3BKMT2ADAO | |
| SCHEMBL23792897 | 0.92 | PDE3A (0.34) | CRBNPDE3APDE3BKCNH2HRH3 | |
| SCHEMBL4457658 | 0.75 | CRBN (0.37) | CRBNPDE3APDE3BDAO | |
| SCHEMBL9246752 | 0.72 | NISCH (0.32) | — | |
| SCHEMBL9143012 | 0.72 | NISCH (0.36) | CRBN | |
| SCHEMBL11080903 | 0.71 | CRBN (0.36) | CRBNPDE3APDE3B | |
| SCHEMBL5186764 | 0.70 | NISCH (0.33) | CRBN | |
| SCHEMBL1022057 | 0.70 | NISCH (0.33) | CRBN | |
| SCHEMBL3337457 | 0.70 | — | — | |
| SCHEMBL14991214 | 0.69 | PDE3A (0.31) | PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478837-A | HYPOTENSIVE AGENTS | SANDOZ LTD. (CH) | 1984-10-23 | — | — | US | disclosed |
| US-3954754-A | ANTIHYPERTENSIVES | SANDOZ LTD. (CH) | 1976-05-04 | — | — | US | disclosed |