Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23792897 | 0.74 | PDE3A (0.34) | CRBNPDE3APDE3B | |
| SCHEMBL11086685 | 0.71 | CRBN (0.35) | CRBNPDE3APDE3B | |
| SCHEMBL11082757 | 0.71 | CRBN (0.35) | CRBNPDE3APDE3B | |
| SCHEMBL14991214 | 0.64 | PDE3A (0.31) | PDE3A | |
| SCHEMBL3533516 | 0.61 | — | — | |
| SCHEMBL20991137 | 0.59 | NOS3 (0.30) | — | |
| SCHEMBL9924735 | 0.58 | TLR4 (0.42) | — | |
| SCHEMBL21729825 | 0.58 | NOS3 (0.33) | — | |
| SCHEMBL19420080 | 0.58 | CRBN (0.39) | CRBN | |
| SCHEMBL13562185 | 0.58 | CRBN (0.39) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478837-A | HYPOTENSIVE AGENTS | SANDOZ LTD. (CH) | 1984-10-23 | — | — | US | disclosed |
| US-3954754-A | ANTIHYPERTENSIVES | SANDOZ LTD. (CH) | 1976-05-04 | — | — | US | disclosed |