Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10395252 | 0.70 | NR4A2 (0.60) | MAPK14ACHEDYRK1AGCGR | |
| SCHEMBL11050177 | 0.68 | ACHE (0.56) | MAPK14ACHECHEK1ALDH1A1MAPT | |
| SCHEMBL29548318 | 0.67 | ACHE (0.63) | MAPK14ACHECLK1CLK2DYRK1A | |
| SCHEMBL27097906 | 0.67 | ACHE (0.63) | MAPK14ACHECLK1CLK2DYRK1A | |
| SCHEMBL6643643 | 0.67 | MAPK14 (1.00) | MAPK14CLK4GCGRMAPK13MAPK12 | |
| SCHEMBL24038370 | 0.66 | RPS6KA3 (0.59) | MAPK14ALDH1A1PKMCLK4RPS6KA3 | |
| SCHEMBL29827056 | 0.66 | NR4A2 (0.50) | MAPK14ACHEDYRK1APDE10AGCGR | |
| SCHEMBL1922154 | 0.65 | MAPK14 (0.51) | MAPK14ACHEALDH1A1PKMCLK2 | |
| SCHEMBL28523404 | 0.64 | ACHE (0.44) | MAPK14ACHEPDE10AMAPTCHUK | |
| SCHEMBL16455592 | 0.63 | CYP17A1 (0.55) | MAPK14RPS6KA3GCGRMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451655-A | Process for preparing carboline derivatives and compounds used in their preparation | PFIZER INC. (US) | 1984-05-29 | — | — | US | claimed |
| EP-0094774-A2 | Carboline derivatives | PFIZER INC. (US) | 1983-11-23 | — | — | EP | claimed |
| US-4451655-A | Process for preparing carboline derivatives and compounds used in their preparation | PFIZER INC. (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0094774-A2 | Carboline derivatives | PFIZER INC. (US) | 1983-11-23 | — | — | EP | disclosed |