Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.68 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16477690 | 0.85 | KDR (0.77) | KDRCA1CA2CA7CA9 | |
| SCHEMBL11461838 | 0.85 | POLB (0.63) | CA2CA9LMNAMAPTRAB9A | |
| SCHEMBL11464764 | 0.84 | KDR (0.63) | KDRCA1CA2CA7CA9 | |
| SCHEMBL29364392 | 0.82 | KDR (1.00) | KDRCA1CA2CA7CA9 | |
| SCHEMBL118026 | 0.82 | KDR (1.00) | KDRCA1CA2CA7CA9 | |
| SCHEMBL11340346 | 0.82 | HTT (0.72) | CA2ARLMNAGAAMAPT | |
| SCHEMBL11463831 | 0.80 | MEN1 (0.62) | LMNAGAAMAPTRAB9ASLC6A3 | |
| SCHEMBL12413876 | 0.79 | KDR (0.82) | KDRCA1CA2CA7CA9 | |
| SCHEMBL2096593 | 0.79 | KDR (0.71) | KDRCA1CA2CA7CA9 | |
| SCHEMBL12319881 | 0.79 | KDR (0.76) | KDRCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482739-A | INTERMEDIATES FOR ANTIANDROGENS AND PARASITICIDES | HOFFMANN-LA ROCHE INC. (US) | 1984-11-13 | — | — | US | disclosed |
| US-4407814-A | ANTIANDROGENS, 3-(HALO- AND/OR TRIFULOROMETHYL-PHENYL)-4,4-DIMETHYL-HYDANTOINS AND IMINO DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0001813-B1 | IMIDAZOLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR USE IN THIS PROCESS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-11-04 | — | — | EP | disclosed |
| US-4234736-A | FLUOROPHENYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1980-11-18 | — | — | US | disclosed |
| EP-0001813-A1 | Imidazolidine derivatives, process for their preparation, intermediates for use in this process, pharmaceutical compositions containing them and the use of the active compounds | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-05-16 | — | — | EP | disclosed |