Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11092755 | 0.95 | MAPK14 (0.56) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| Flumizole SCHEMBL15757137 | 0.85 | ESR1 (0.58) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| Flumizole SCHEMBL43779 | 0.85 | ESR1 (0.58) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| SCHEMBL11087907 | 0.84 | ESR1 (0.47) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL11164692 | 0.83 | NOX1 (0.50) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| SCHEMBL11165161 | 0.83 | NOX1 (0.53) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| SCHEMBL11082923 | 0.82 | BRAF (0.57) | MAPK13MAPK12MAPK11MAPK14ALOX5 | |
| SCHEMBL11177941 | 0.82 | NOX1 (0.52) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| SCHEMBL11177151 | 0.80 | NOX1 (0.50) | NOX1PDE10AMAPK13MAPK12MAPK11 | |
| SCHEMBL11182862 | 0.79 | NOX1 (0.49) | NOX1PDE10AMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348404-A | ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-07 | — | — | US | claimed |
| EP-0044486-A1 | Antiinflammatory 4,5-diaryl-alpha-polyfluoroalkyl-1H-imidazole-2-methanamines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-27 | — | — | EP | claimed |
| US-4478845-A | Antiinflammatory and/or analgesic imidazoimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-10-23 | — | — | US | disclosed |
| US-4348404-A | ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-07 | — | — | US | disclosed |
| US-4348404-A | ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-07 | — | — | US | disclosed |
| EP-0044486-A1 | Antiinflammatory 4,5-diaryl-alpha-polyfluoroalkyl-1H-imidazole-2-methanamines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-27 | — | — | EP | disclosed |
| EP-0044486-A1 | Antiinflammatory 4,5-diaryl-alpha-polyfluoroalkyl-1H-imidazole-2-methanamines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-27 | — | — | EP | disclosed |