SCHEMBL11088046

SCHEMBL11088046

[c]1ccc(OCN2CCOCC2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.46
ESR2 Q92731 1/20 0.46
MAPK1 P28482 2/20 0.45
HRH3 Q9Y5N1 2/20 0.45
ALDH1A1 P00352 1/20 0.45
CYP1A2 P05177 1/20 0.45
CHRM2 P08172 1/20 0.45
CHRM1 P11229 1/20 0.45
HTR2A P28223 1/20 0.45
SCN1A P35498 1/20 0.45
HTR2B P41595 1/20 0.45
KCNH2 Q12809 1/20 0.45
SCN2A Q99250 1/20 0.45
SIGMAR1 Q99720 1/20 0.45
SCN3A Q9NY46 1/20 0.45
USP2 O75604 1/20 0.44
LMNA P02545 1/20 0.44
HRH2 P25021 1/20 0.42
HRH1 P35367 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3951665 0.83 HRH3 (0.41) ESR1ESR2HRH3KCNH2HRH2
SCHEMBL20029 0.83 NPC1 (0.61) MAPK1HRH3ALDH1A1CYP1A2CHRM2
SCHEMBL5656590 0.81 HRH3 (0.43) ESR1ESR2HRH3KCNH2TSHR
SCHEMBL255055 0.81 ESR1 (0.58) ESR1ESR2MAPK1HRH3ALDH1A1
SCHEMBL1442766 0.81 HRH3 (0.69) MAPK1HRH3ALDH1A1CYP1A2CHRM2
SCHEMBL14100110 0.79 ESR1 (0.49) ESR1ESR2MAPK1HRH3ALDH1A1
SCHEMBL8927890 0.79 SMN1; SMN2 (0.65) ESR1ESR2MAPK1HRH3ALDH1A1
SCHEMBL9051947 0.79 ALDH1A1 (0.55) ESR1ESR2MAPK1HRH3ALDH1A1
SCHEMBL3141711 0.74 NPC1 (0.72) MAPK1HRH3ALDH1A1CYP1A2CHRM2
SCHEMBL3141155 0.73 HRH3 (0.73) MAPK1HRH3ALDH1A1CYP1A2CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452789-A CARDIOVASCULAR DISORDERS BOEHRINGER INGELHEIM KG (DE) 1984-06-05 US disclosed