SCHEMBL11089207

SCHEMBL11089207

CCN(c1ccccc1)c1ncnc2cc(Cl)ccc12

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 8/20 0.63
EGFR P00533 8/20 0.63
KDM4E B2RXH2 3/20 0.49
HPGD P15428 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
CHKA P35790 1/20 0.48
TP53 P04637 2/20 0.45
RXFP1 Q9HBX9 2/20 0.43
PPARG P37231 1/20 0.43
NR2E3 Q9Y5X4 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
ALDH1A1 P00352 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
PDGFRB P09619 1/20 0.40
PDGFRA P16234 1/20 0.40
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11090064 0.99 CSF1R (0.64) CSF1REGFRKDM4EHPGDSMN1; SMN2
SCHEMBL11083826 0.82 CSF1R (0.79) CSF1REGFRCHKAPDGFRBPDGFRA
Hydrochloric Acid SCHEMBL11094140 0.81 CSF1R (0.77) CSF1REGFRCHKAPDGFRBPDGFRA
Hydrochloric Acid SCHEMBL8375181 0.79 HTT (0.54) CSF1REGFRKDM4EHPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL8808017 0.78 EGFR (0.61) CSF1REGFRKDM4EHPGDSMN1; SMN2
SCHEMBL8177845 0.77 EGFR (1.00) CSF1REGFRKDM4EHPGDTP53
Hydrochloric Acid SCHEMBL6181342 0.76 EGFR (1.00) CSF1REGFRTP53PDGFRBPDGFRA
SCHEMBL4741965 0.76 EGFR (0.63) CSF1REGFRKDM4EHPGDSMN1; SMN2
SCHEMBL29058418 0.76 CSF1R (0.63) CSF1REGFRKDM4EHPGDSMN1; SMN2
SCHEMBL6184794 0.75 EGFR (0.76) CSF1REGFRKDM4EHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4464375-A ANALGESIC, ANTIINFLAMMATORY SANKYO CO., LTD. (JP) 1984-08-07 US disclosed
US-4322420-A Method of using 4-anilinoquinazoline derivatives as analgesic and anti-inflammatory agents SANKYO COMPANY LIMITED (JP) 1982-03-30 US disclosed