Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | CSF1R | P07333 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29058418 | 0.84 | CSF1R (0.63) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL3645660 | 0.79 | CSF1R (0.58) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL4741361 | 0.79 | EGFR (0.82) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL8808017 | 0.78 | EGFR (0.61) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL8177845 | 0.77 | EGFR (1.00) | EGFRCSF1RKDM4EHPGDTP53 | |
| SCHEMBL29058819 | 0.77 | CSF1R (0.55) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL30395607 | 0.77 | CSF1R (0.55) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL6181342 | 0.76 | EGFR (1.00) | EGFRCSF1RTP53RETKIF5B | |
| SCHEMBL5499105 | 0.76 | EGFR (0.51) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL11089207 | 0.76 | CSF1R (0.63) | EGFRCSF1RSMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |