Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RRM1 | P23921 | 1/20 | 0.47 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603750 | 0.89 | MAPT (0.55) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL11093012 | 0.88 | GAA (0.48) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL11093016 | 0.88 | MAPT (0.48) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL3606683 | 0.88 | CSNK2A1 (0.58) | MAPTNPC1RAB9AGAANPSR1 | |
| Bromide SCHEMBL7142457 | 0.87 | CSNK2A1 (0.57) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL11085009 | 0.87 | ABL1 (0.49) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL11085002 | 0.87 | ABL1 (0.49) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL3615155 | 0.86 | ALOX5 (0.51) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL2393684 | 0.86 | HDAC3 (0.59) | MAPTNPC1RAB9AGAANPSR1 | |
| SCHEMBL3602570 | 0.86 | ABL1 (0.67) | NPC1RAB9AABL1VCPPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452985-A | 2-Guanyl-4-(substituted phenyl) thiazole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-05 | — | — | US | disclosed |