⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12846927 | 0.80 | — | — | |
| SCHEMBL18964649 | 0.80 | — | — | |
| SCHEMBL2290316 | 0.71 | — | — | |
| SCHEMBL10210478 | 0.69 | — | — | |
| SCHEMBL9830002 | 0.69 | — | — | |
| SCHEMBL14669194 | 0.67 | — | — | |
| SCHEMBL1470777 | 0.66 | — | — | |
| SCHEMBL1414467 | 0.65 | — | — | |
| SCHEMBL12070427 | 0.64 | — | — | |
| SCHEMBL220016 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580442-B2 | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors | KARUS THERAPEUTICS LIMITED (GB) | 2017-02-28 | — | — | US | disclosed |
| US-20160368904-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2016-12-22 | — | — | US | disclosed |
| US-20160130282-A1 | MERCAPTOAMIDINE DERIVATIVES AND METHODS OF USE | ABBVIE INC. | 2016-05-12 | — | — | US | disclosed |
| US-20160108057-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS | CONVALIFE (SHANGHAI) CO. LIMITED (CN) | 2016-04-21 | — | — | US | disclosed |
| US-9200007-B2 | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors | KARUS THERAPEUTICS LIMITED (GB) | 2015-12-01 | — | — | US | disclosed |
| US-9181275-B2 | Mercaptoamidine derivatives and methods of use | ABBVIE INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-8580968-B2 | Benzothiazole and benzooxazole derivatives and methods of use | ABBVIE INC. (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| US-20130040940-A1 | MERCAPTOAMIDINE DERIVATIVES AND METHODS OF USE | ABBVIE INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20120178737-A1 | Tricyclic Heterocyclic Compounds as Phosphoinositide 3-Kinase Inhibitors | CONVALIFE (SHANGHAI) CO. LIMITED (CN) | 2012-07-12 | — | — | US | disclosed |
| US-8153813-B2 | Benzothiazole and benzooxazole derivatives and methods of use | ABBOTT LABORATORIES (US) | 2012-04-10 | — | — | US | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011119565-A1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| US-20110207704-A1 | Novel Oxadiazole Compounds | ABBOTT LABORATORIES (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-20090326222-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-7576110-B2 | Benzothiazole cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-08-18 | — | — | US | disclosed |
| US-20090163464-A1 | BENZOTHIAZOLE AND BENZOOXAZOLE DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2009-06-25 | — | — | US | disclosed |
| WO-2007038074-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2007-04-05 | — | — | WO | disclosed |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. | 2007-03-22 | — | — | US | disclosed |