Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.51 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088749 | 0.89 | AKT1 (0.47) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| Maleic Acid SCHEMBL11083525 | 0.89 | P2RY1 (0.47) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| Fumaric Acid SCHEMBL11083528 | 0.89 | P2RY1 (0.47) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| SCHEMBL11085290 | 0.88 | AKT1 (0.42) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| SCHEMBL11270522 | 0.84 | AKT1 (0.55) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| SCHEMBL11096561 | 0.83 | AKT1 (0.49) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| SCHEMBL11083514 | 0.82 | AKT1 (0.54) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| Hydrochloric Acid SCHEMBL11096203 | 0.82 | AKT1 (0.54) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| SCHEMBL11089304 | 0.82 | AKT1 (0.53) | AKT1P2RY1HDAC1HDAC6SLC18A3 | |
| SCHEMBL11095431 | 0.82 | AKT1 (0.38) | AKT1P2RY1SLC18A3SIGMAR1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | claimed |
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | claimed |
| US-4477667-A | Spiro[indoline-3,4'-piperidine]s and related compounds | AMERICAN HOECHST CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4408050-A | Spiro(indoline-3,4'-piperidine) and related compounds | AMERICAN HOECHST CORPORATION (US) | 1983-10-04 | — | — | US | disclosed |
| US-4379932-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379933-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| US-4307235-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |