Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11096203 | 0.98 | AKT1 (0.54) | AKT1ADRA2CP2RY1SLC18A3HDAC1 | |
| SCHEMBL11093661 | 0.88 | AKT1 (0.50) | AKT1ADRA2CP2RY1SLC18A3HDAC1 | |
| Hydrochloric Acid SCHEMBL11090426 | 0.84 | AKT1 (0.43) | AKT1ADRA2CP2RY1SLC18A3HDAC1 | |
| SCHEMBL11083514 | 0.84 | AKT1 (0.54) | AKT1ADRA2CP2RY1SLC18A3HDAC1 | |
| SCHEMBL11091981 | 0.84 | AKT1 (0.51) | AKT1ADRA2CP2RY1SLC18A3HDAC1 | |
| SCHEMBL11089304 | 0.83 | AKT1 (0.53) | AKT1ADRA2CP2RY1SLC18A3HDAC1 | |
| SCHEMBL11373937 | 0.81 | P2RY1 (0.55) | AKT1P2RY1SLC18A3HDAC1HDAC6 | |
| SCHEMBL1572642 | 0.81 | P2RY1 (0.53) | AKT1P2RY1OPRM1 | |
| SCHEMBL2883895 | 0.80 | SLC18A3 (0.61) | AKT1P2RY1SLC18A3HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL11085178 | 0.80 | P2RY1 (0.54) | AKT1P2RY1SLC18A3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | claimed |
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | claimed |