SCHEMBL11094397

SCHEMBL11094397

Cc1cc(N)ccc1C(OC(c1ccccc1)c1ccc(N)cc1C)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.46
ALDH1A1 P00352 1/20 0.41
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP2C9 P11712 2/20 0.39
SLC22A2 O15244 1/20 0.39
SLC22A1 O15245 1/20 0.39
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
CHRM2 P08172 1/20 0.39
CHRM4 P08173 1/20 0.39
CHRM5 P08912 1/20 0.39
ADRA2A P08913 1/20 0.39
CHRM1 P11229 1/20 0.39
ADRA2B P18089 1/20 0.39
CHRM3 P20309 1/20 0.39
DRD1 P21728 1/20 0.39
SLC6A2 P23975 1/20 0.39
HRH2 P25021 1/20 0.39
HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11777251 0.86 ALDH1A1 (0.41) ESR1ALDH1A1CYP3A4LMNAIDO1
SCHEMBL11088161 0.86 ESR1 (0.46) ESR1ALDH1A1CYP2D6CYP2C19CYP2C9
SCHEMBL22044344 0.80 ALDH1A1 (0.45) ALDH1A1CYP2C19CYP2C9CYP3A4LMNA
SCHEMBL11088729 0.80 IDO1 (0.53) ALDH1A1ADRA2BLMNAIDO1TDO2
SCHEMBL11777166 0.79 IDO1 (0.55) ALDH1A1CYP2C19CYP2C9CYP3A4PMP22
SCHEMBL5268174 0.77 ESR1 (0.75) ESR1CYP2D6CYP2C19CYP2C9SLC22A2
Dimethylamine SCHEMBL10776405 0.76 ALDH1A1 (0.41) ALDH1A1CYP2C19CYP2C9GRIN2DGRIN3B
SCHEMBL9297488 0.76 ALDH1A1 (0.41) ALDH1A1CYP2D6CYP2C19CYP2C9CHRM1
SCHEMBL11518804 0.76 ESR1 (0.41) ESR1ALDH1A1CYP2D6CYP2C19CYP2C9
SCHEMBL3924304 0.73 IDO1 (0.47) ALDH1A1CYP2D6CYP2C19CYP2C9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0113922-A2 Process for the manufacture of cationic methine dyes BAYER AG (DE) 1984-07-25 EP disclosed
EP-0113921-A2 Process for the manufacture of stable solutions of cationic methine dyes BAYER AG (DE) 1984-07-25 EP disclosed
EP-0113920-A2 Process for the manufacture of stable solutions of cationic methine dyes, and their use in spin dyeing BAYER AG (DE) 1984-07-25 EP disclosed
US-3956264-A Basic azo dyestuffs having indolyl-methyleneamino substituent in the diazo component BAYER AKTIENGESELLSCHAFT (DT) 1976-05-11 US disclosed