Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094637 | 1.00 | KMT2A (0.52) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL11094634 | 1.00 | KMT2A (0.52) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL1171653 | 0.81 | KMT2A (0.57) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL1171649 | 0.81 | KMT2A (0.57) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL11091013 | 0.81 | KMT2A (0.57) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL7622115 | 0.80 | KMT2A (0.56) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL7622118 | 0.80 | KMT2A (0.56) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL7622111 | 0.80 | KMT2A (0.56) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL11388422 | 0.80 | ALDH1A1 (0.57) | KMT2AKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL11095753 | 0.79 | KMT2A (0.49) | KMT2AKDM4EMEN1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461906-A | IMPROVING INTELLECTUAL CAPACITY | HOFFMANN-LA ROCHE INC. (US) | 1984-07-24 | — | — | US | disclosed |
| EP-0024030-B1 | PYRROLIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-03-30 | — | — | EP | disclosed |
| EP-0024030-A1 | Pyrrolidine derivatives, processes for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-02-18 | — | — | EP | disclosed |