Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2971279 | 0.96 | HRH1 (0.46) | HRH1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5706851 | 0.92 | HRH1 (0.48) | HRH1TAAR1TDP1SLC6A2SLC6A4 | |
| SCHEMBL7315744 | 0.90 | HRH1 (0.44) | HRH1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11125795 | 0.86 | HRH1 (0.44) | HRH1TAAR1TDP1SLC6A2SLC6A4 | |
| SCHEMBL6503487 | 0.85 | HRH1 (0.62) | HRH1SLC6A2SLC6A4SLC6A3RIPK1 | |
| SCHEMBL28791116 | 0.83 | TDP1 (0.46) | TAAR1TDP1SLC6A4MPO | |
| SCHEMBL79353 | 0.80 | TAAR1 (0.60) | TAAR1MPOSIGMAR1AOC3 | |
| SCHEMBL16111413 | 0.80 | HRH1 (0.67) | HRH1TDP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30118964 | 0.80 | TAAR1 (0.60) | TAAR1MPOSIGMAR1AOC3 | |
| SCHEMBL11142333 | 0.78 | SLC6A4 (0.55) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057777-B1 | DIBENZOXAZONINE, DIBENZOXAZECINE, DIBENZOXAAZACYCLOUNDECANE DERIVATIVES AND THEIR CORRESPONDING THIA- AND AZA DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-10 | — | — | EP | disclosed |
| US-4374133-A | PSYCHOLOGICAL DISORDERS | AKZO N.V. (NL) | 1983-02-15 | — | — | US | disclosed |
| WO-1982002199-A1 | TRICYCLIC COMPOUNDS | AKZO NV (NL) | 1982-07-08 | — | — | WO | disclosed |