Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | SHBG | P04278 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10795475 | 0.90 | HSD17B10 (0.69) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL11875499 | 0.89 | HSD17B10 (0.67) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL11577800 | 0.89 | HSD17B10 (0.67) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL10794411 | 0.88 | HSD17B10 (0.66) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL7885569 | 0.86 | LMNA (0.64) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL3868012 | 0.85 | ESR1 (0.67) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL11097284 | 0.85 | ESR1 (0.67) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL548134 | 0.85 | ESR1 (0.67) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL11577051 | 0.83 | LMNA (0.64) | HSD17B10LMNACYP19A1MAPTCYP1A2 | |
| SCHEMBL8621058 | 0.82 | ESR1 (0.74) | HSD17B10LMNACYP19A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044105-B1 | NEW 8-ALPHA-OESTRA-1,3,5(10)-TRIENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-03 | — | — | EP | disclosed |