Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TET3 | O43151 | 1/20 | 0.57 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.57 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.57 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.57 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.57 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31001015 | 0.94 | KMT2A (0.52) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL301027 | 0.88 | KMT2A (0.64) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL8179850 | 0.87 | F10 (0.47) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL16287573 | 0.86 | KCNA3 (0.48) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL3443266 | 0.85 | KMT2A (0.61) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL503291 | 0.85 | KMT2A (0.65) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL19438755 | 0.85 | KMT2A (0.54) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL21874269 | 0.83 | KMT2A (0.63) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL503877 | 0.83 | KMT2A (0.63) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL11047671 | 0.83 | F10 (0.48) | KMT2ATET3FBXL19CXXC5TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
| US-3979444-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, HYPOTENSIVES | THE UPJOHN COMPANY (US) | 1976-09-07 | — | — | US | disclosed |