Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.41 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179850 | 0.83 | F10 (0.47) | F10KCNA3CYP3A4CYP2C19POLB | |
| SCHEMBL11096445 | 0.83 | KMT2A (0.57) | KCNA3CYP3A4CYP2C19OPRM1OPRL1 | |
| SCHEMBL16287573 | 0.82 | KCNA3 (0.48) | F10KCNA3CYP3A4CYP2C19POLB | |
| SCHEMBL24203744 | 0.81 | SMN1; SMN2 (0.56) | EP300NCOA1NCOA3KCNA3OPRM1 | |
| SCHEMBL11044409 | 0.79 | POLB (0.50) | F10EP300NCOA1NCOA3CYP3A4 | |
| SCHEMBL31001015 | 0.78 | KMT2A (0.52) | KCNA3CYP3A4CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL3404808 | 0.76 | OPRM1 (0.65) | F10KCNA3OPRM1OPRL1POLB | |
| SCHEMBL613812 | 0.74 | OPRM1 (0.50) | KCNA3OPRM1OPRL1POLBALDH1A1 | |
| SCHEMBL11823191 | 0.72 | KCNA3 (0.44) | KCNA3CYP3A4CYP2C19OPRM1OPRL1 | |
| SCHEMBL612898 | 0.71 | MAOB (0.43) | F10KCNA3OPRM1OPRL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035902-B1 | 1-(4-ARYL-CYCLOHEXYL)PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-10-31 | — | — | EP | disclosed |
| US-4329353-A | ANTIEMETIC AND NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-05-11 | — | — | US | disclosed |
| EP-0035902-A1 | 1-(4-Aryl-cyclohexyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-09-16 | — | — | EP | disclosed |