Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | TET3 | O43151 | 2/20 | 0.37 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.37 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.37 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butylamine SCHEMBL15352312 | 0.91 | AKR1C1 (0.40) | AKR1C1HSD11B1KMT2AMEN1CYP2C9 | |
| SCHEMBL2221 | 0.87 | AKR1C1 (0.55) | AKR1C1KMT2AMEN1CYP2C9TSHR | |
| SCHEMBL3910628 | 0.85 | AKR1C1 (0.53) | AKR1C1KMT2AMEN1CYP2C9TSHR | |
| SCHEMBL19358562 | 0.84 | HSD11B1 (0.40) | HSD11B1KMT2AMEN1CYP2C9HDAC1 | |
| SCHEMBL631791 | 0.83 | AKR1C1 (0.68) | AKR1C1HSD11B1KMT2AMEN1CYP2C9 | |
| SCHEMBL9966557 | 0.83 | AKR1C1 (0.68) | AKR1C1HSD11B1KMT2AMEN1TSHR | |
| Water SCHEMBL3910626 | 0.83 | AKR1C1 (0.52) | AKR1C1KMT2AMEN1CYP2C9TSHR | |
| SCHEMBL1492737 | 0.83 | AKR1C1 (0.62) | AKR1C1HSD11B1KMT2AMEN1CYP2C9 | |
| SCHEMBL11075416 | 0.82 | KMT2A (0.54) | AKR1C1HSD11B1KMT2AMEN1CYP2C9 | |
| SCHEMBL5768239 | 0.82 | CYP2C9 (0.50) | AKR1C1HSD11B1KMT2AMEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852590-B1 | CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS | NOVARTIS AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| EP-2852590-B1 | CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS | NOVARTIS AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| EP-2852590-A1 | CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS | Novartis AG (CH) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013160873-A1 | CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS | NOVARTIS AG (CH) | 2013-10-31 | — | — | WO | disclosed |
| WO-2013160873-A1 | CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS | NOVARTIS AG (CH) | 2013-10-31 | — | — | WO | disclosed |
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |