Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11479791 | 0.75 | LIMK1 (0.52) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL20467172 | 0.69 | LIMK1 (0.52) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL11478409 | 0.68 | KDM4E (0.60) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL19805093 | 0.65 | LIMK1 (0.53) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL4892520 | 0.65 | LIMK1 (0.72) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL19805136 | 0.64 | LIMK1 (0.71) | LIMK1NPC1RAB9AMAPTMEN1 | |
| SCHEMBL11478003 | 0.64 | LIMK1 (0.49) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL4901470 | 0.64 | LIMK1 (1.00) | LIMK1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL19805138 | 0.62 | LIMK1 (0.56) | LIMK1NPC1RAB9AMAPTHTT | |
| SCHEMBL9995225 | 0.62 | RAB9A (0.46) | LIMK1NPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0066124-B1 | PYRIDOTHIENOPYRIDAZINE COMPOUNDS | USV PHARMACEUTICAL CORPORATION (US) | 1984-09-19 | — | — | EP | disclosed |
| EP-0066124-A1 | Pyridothienopyridazine compounds | USV PHARMACEUTICAL CORPORATION (US) | 1982-12-08 | — | — | EP | disclosed |
| US-4355164-A | Pyridothienopyridazine anti-allergy compounds | USV PHARMACEUTICAL CORPORATION (US) | 1982-10-19 | — | — | US | disclosed |