Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 15/20 | 1.00 |
| ▸ | PDE4A | P27815 | 2/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | PDE2A | O00408 | 2/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204857 | 0.84 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10646735 | 0.79 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7272078 | 0.78 | PDE3B (0.64) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL11090412 | 0.78 | PDE3B (0.63) | PDE3BPDE3ALMNAMEN1KMT2A | |
| Ci-930 SCHEMBL6052113 | 0.78 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10651787 | 0.77 | PDE3B (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10657390 | 0.77 | PDE3B (0.98) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10761383 | 0.77 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Imazodan SCHEMBL148436 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL10757069 | 0.76 | PDE3B (0.72) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |
| EP-0090978-A2 | Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1983-10-12 | — | — | EP | disclosed |