Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 15/20 | 0.74 |
| ▸ | TNKS2 | Q9H2K2 | 15/20 | 0.74 |
| ▸ | PARP1 | P09874 | 7/20 | 0.74 |
| ▸ | PARP2 | Q9UGN5 | 8/20 | 0.69 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568249 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL11100167 | 0.86 | TNKS (0.66) | TNKSTNKS2PARP1PARP2CYP1B1 | |
| SCHEMBL15775173 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775361 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL165829 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL1387257 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775410 | 0.80 | TNKS (1.00) | TNKSTNKS2PARP1PARP2CYP1B1 | |
| SCHEMBL15775274 | 0.80 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL11102850 | 0.80 | TNKS (0.79) | TNKSTNKS2PARP1PARP2GUSB | |
| Hydrochloric Acid SCHEMBL28060794 | 0.80 | TNKS (0.97) | TNKSTNKS2PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054132-B1 | PYRIMIDONES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-10-10 | — | — | EP | disclosed |
| US-4379788-A | HYPOTENSIVES, ANTIARRHYTHMIA, B-BLOCKERS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-04-12 | — | — | US | disclosed |