Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099376 | 1.00 | MAPK1 (0.66) | MAPK1TDP1CES1ESR1CYP19A1 | |
| SCHEMBL11105844 | 0.83 | MAPK1 (0.63) | MAPK1TDP1CES1ESR1CYP19A1 | |
| SCHEMBL11105826 | 0.83 | MAPK1 (0.63) | MAPK1TDP1CES1ESR1CYP19A1 | |
| SCHEMBL11025481 | 0.81 | ESR1 (0.57) | MAPK1TDP1CES1ESR1CYP19A1 | |
| SCHEMBL13370393 | 0.81 | ESR1 (0.57) | MAPK1TDP1CES1ESR1CYP19A1 | |
| Acetic Acid SCHEMBL27877969 | 0.81 | MAPK1 (0.71) | MAPK1TDP1CES1CA1CA2 | |
| Acetic Acid SCHEMBL28719519 | 0.80 | MAPK1 (0.92) | MAPK1TDP1CES1CA1CA2 | |
| SCHEMBL23727567 | 0.80 | MAPK1 (0.54) | MAPK1TDP1CES1ESR1CYP19A1 | |
| SCHEMBL8726612 | 0.79 | MAPK1 (0.69) | MAPK1TDP1CES1ESR1CYP19A1 | |
| SCHEMBL27765 | 0.79 | MAPK1 (1.00) | MAPK1TDP1CES1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047119-B1 | CARBOXAMIDE COMPOUNDS AS SRS-A ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THE PREPARATION, AND INTERMEDIATES USEFUL THEREIN | PFIZER INC. (US) | 1984-05-09 | — | — | EP | disclosed |
| US-4343813-A | ANTIANAPHYLACTIC AGENTS | PFIZER INC. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4331683-A | SENSITIZATION, ANTIALLERGENS | PFIZER INC. (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0047119-A1 | Carboxamide compounds as SRS-A antagonists, pharmaceutical compositions containing them, processes for the preparation, and intermediates useful therein | PFIZER INC. (US) | 1982-03-10 | — | — | EP | disclosed |
| US-4296129-A | ANTIAASTHMATIC INHIBITOR OF SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS | PFIZER, INC. (US) | 1981-10-20 | — | — | US | disclosed |
| US-4296120-A | ANTIANAPHYLACTIC | PFIZER INC. (US) | 1981-10-20 | — | — | US | disclosed |