Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095062 | 0.78 | PDE3B (0.38) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11099638 | 0.78 | PDE3B (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Motapizone SCHEMBL385669 | 0.77 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL11102712 | 0.77 | PDE3B (0.58) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Motapizone SCHEMBL10671058 | 0.76 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10646735 | 0.70 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10364636 | 0.69 | PDE3B (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10365546 | 0.69 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL10367316 | 0.68 | PDE3B (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL10366285 | 0.68 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |