Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.65 |
| ▸ | PDE4A | P27815 | 3/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.65 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Motapizone SCHEMBL10671058 | 0.99 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10730608 | 0.86 | PDE3B (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11062828 | 0.80 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11062826 | 0.80 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Motapizone SCHEMBL6560835 | 0.80 | PDE4A (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Motapizone SCHEMBL7882980 | 0.80 | PDE3A (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10729410 | 0.80 | PBRM1 (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10646735 | 0.80 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL6052113 | 0.79 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10365546 | 0.79 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1347 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240002440-A1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | JPMORGAN CHASE BANK, N.A. | 2024-01-04 | — | — | US | claimed |
| US-20210379142-A1 | AGONISTS OF GUANYLATE CYCLASE AND THEIR USES | BAUSCH HEALTH COMPANIES INC. (CA) | 2021-12-09 | — | — | US | claimed |
| US-10967043-B2 | Agonists of guanylate cyclase and their uses | BAUSCH HEALTH IRELAND LIMITED (IE) | 2021-04-06 | — | — | US | claimed |
| EP-3054969-B1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF OPIOID INDUCED DYSFUNCTIONS | BAUSCH HEALTH IRELAND LTD (IE) | 2021-03-10 | — | — | EP | claimed |
| EP-3718557-A2 | GUANYLATE CYCLASE RECEPTOR AGONIST SP-333 FOR USE IN COLONIC CLEANSING | Bausch Health Ireland Limited (IE) | 2020-10-07 | — | — | EP | claimed |
| US-20200283480-A1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | BAUSCH HEALTH COMPANIES INC. (CA) | 2020-09-10 | — | — | US | claimed |
| EP-3621593-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | Cardix Therapeutics LLC (US) | 2020-03-18 | — | — | EP | claimed |
| US-20200054709-A1 | AGONISTS OF GUANYLATE CYCLASE AND THEIR USES | BAUSCH HEALTH COMPANIES INC. (CA) | 2020-02-20 | — | — | US | claimed |
| EP-2944648-B1 | Guanylate cyclase receptor agonists for the treatment of organ inflammation | BAUSCH HEALTH IRELAND LTD (IE) | 2019-11-13 | — | — | EP | claimed |
| WO-2019194866-A1 | DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | Cardix Therapeutics LLC (US) | 2019-10-10 | — | — | WO | claimed |
| WO-2000012076-A1 | NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-03-09 | — | — | WO | claimed |
| EP-0977559-A1 | ENHANCED ANTI-CANCER AGENT DELIVERY TO SOLID TUMORS BY PRIMER COMPOUNDS | Biophausia AB (SE) | 2000-02-09 | — | — | EP | claimed |
| WO-1999020223-A2 | LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE | NOVO NORDISK A/S (DK) | 1999-04-29 | — | — | WO | claimed |
| WO-1999014239-A1 | COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY | FORSSMANN WOLF GEORG (DE) | 1999-03-25 | — | — | WO | claimed |
| WO-1998055112-A1 | ENHANCED ANTI-CANCER AGENT DELIVERY TO SOLID TUMORS BY PRIMER COMPOUNDS | BIOPHAUSIA AB (SE) | 1998-12-10 | — | — | WO | claimed |
| EP-0156163-B1 | PHARMACEUTICAL PRODUCT FOR THE TREATMENT OF HYPERTENSION AND THROMBOEMBOLIC DISEASES | A. Nattermann & Cie. GmbH (DE) | 1988-11-09 | — | — | EP | claimed |
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | claimed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | claimed |
| EP-0156163-A1 | Pharmaceutical product for the treatment of hypertension and thromboembolic diseases | A. Nattermann & Cie. GmbH (DE) | 1985-10-02 | — | — | EP | claimed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | claimed |