Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11306379 | 0.89 | HTT (0.63) | HTTTP53ALDH1A1MAPTNPSR1 | |
| SCHEMBL11108508 | 0.83 | ALDH1A1 (0.55) | HTTTP53ALDH1A1MAPTNPSR1 | |
| SCHEMBL11103219 | 0.82 | LTB4R2 (0.39) | ALDH1A1MAPTNPSR1KDM4EMEN1 | |
| SCHEMBL11102435 | 0.82 | TSHR (0.46) | TP53ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL11576314 | 0.75 | ALDH1A1 (0.73) | HTTTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL11577825 | 0.75 | ALDH1A1 (0.73) | HTTTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL7586296 | 0.74 | MAPT (0.54) | HTTTP53ALDH1A1MAPTNPSR1 | |
| SCHEMBL3149715 | 0.72 | HTT (1.00) | HTTTP53ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6810968 | 0.71 | ALDH1A1 (0.50) | HTTTP53ALDH1A1MAPTNPSR1 | |
| SCHEMBL3885646 | 0.70 | ALDH1A1 (1.00) | HTTTP53ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063826-B1 | 2-AMINO-BENZOIC-ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES OR INTERMEDIATES | Dr. Karl Thomae GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |
| EP-0063826-A2 | 2-Amino-benzoic-acid derivatives, their preparation and their use as medicines or intermediates | Dr. Karl Thomae GmbH (DE) | 1982-11-03 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |