Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11191933 | 0.87 | ACE (0.58) | ACELMNAFFAR2ALDH1A1POLB | |
| Rentiapril SCHEMBL294980 | 0.87 | ACE (1.00) | ACELMNAFFAR2ALDH1A1POLB | |
| Rentiapril SCHEMBL11065900 | 0.87 | ACE (1.00) | ACELMNAFFAR2ALDH1A1POLB | |
| Rentiapril SCHEMBL323403 | 0.87 | ACE (1.00) | ACELMNAFFAR2ALDH1A1POLB | |
| Rentiapril SCHEMBL30422754 | 0.87 | ACE (1.00) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL11191543 | 0.86 | ACE (0.77) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL683641 | 0.84 | ACE (0.73) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL9149937 | 0.81 | POLB (0.54) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL683207 | 0.80 | ACE (0.87) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL11102513 | 0.78 | ACE (0.68) | ACELMNAFFAR2POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4457935-A | ANGIOTENSIN-CONVERTING ENZYME INHIBITOR | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-07-03 | — | — | US | claimed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |