Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11101859 | 0.99 | ALDH1A1 (0.43) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11096601 | 0.99 | ALDH1A1 (0.43) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11099270 | 0.87 | ALDH1A1 (0.42) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11104031 | 0.86 | CA12 (0.48) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11104379 | 0.85 | ALDH1A1 (0.48) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11096591 | 0.84 | ALDH1A1 (0.45) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11098356 | 0.84 | CISD1 (0.43) | CA12CA1CA2CA4CA6 | |
| Potassium Ion SCHEMBL11100066 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11100710 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CA12CA1CA2CA4 | |
| Potassium Ion SCHEMBL11101257 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034746-B1 | 5-SULFAMOYL-ORTHANILIC ACIDS, PROCESSES FOR THEIR PREPARATION, THERAPEUTIC COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE IN THERAPY | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-01-18 | — | — | EP | disclosed |
| US-4339446-A | 5-Sulfamoyl-orthanilic acids, processes for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-07-13 | — | — | US | disclosed |
| EP-0034746-A1 | 5-Sulfamoyl-orthanilic acids, processes for their preparation, therapeutic compositions containing them and the compounds for use in therapy | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-02 | — | — | EP | disclosed |