Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 3/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15354786 | 0.82 | IRAK4 (0.49) | IRAK4HTR2AHTR7HTR1ADRD2 | |
| SCHEMBL906765 | 0.81 | IRAK4 (0.39) | IRAK4HTR2AHTR7HTR1ADRD2 | |
| SCHEMBL906775 | 0.79 | IRAK4 (0.41) | IRAK4HTR2AHTR7HTR1ADRD2 | |
| SCHEMBL30577788 | 0.79 | IRAK4 (0.41) | IRAK4HTR2AHTR7HTR1ADRD2 | |
| SCHEMBL3465386 | 0.78 | IRAK4 (0.38) | TAAR1IRAK4HTR2AHTR7HTR1A | |
| SCHEMBL2767058 | 0.78 | IRAK4 (0.38) | TAAR1IRAK4HTR2AHTR7HTR1A | |
| SCHEMBL14211421 | 0.78 | IRAK4 (0.38) | TAAR1IRAK4HTR2AHTR7HTR1A | |
| SCHEMBL1986238 | 0.77 | TAAR1 (0.41) | TAAR1LOXL2HTR2AHTR2CHTR2B | |
| SCHEMBL12302975 | 0.77 | IRAK4 (0.36) | IRAK4HTR2AHTR7HTR1ADRD2 | |
| SCHEMBL18599465 | 0.77 | IRAK4 (0.36) | IRAK4HTR2AHTR7HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |