Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15354786 | 0.82 | IRAK4 (0.49) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL1111000 | 0.81 | TAAR1 (0.41) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL988633 | 0.80 | S1PR2 (0.39) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL30577788 | 0.79 | IRAK4 (0.41) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL906775 | 0.79 | IRAK4 (0.41) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL3508916 | 0.78 | S1PR2 (0.35) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL22834772 | 0.78 | S1PR2 (0.35) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL29651896 | 0.78 | S1PR2 (0.35) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL18415006 | 0.78 | IRAK4 (0.38) | IRAK4HTR7HTR1ADRD2HTR2A | |
| SCHEMBL31691990 | 0.78 | IRAK4 (0.38) | IRAK4HTR7HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276759-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | Eli Lilly & Company (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123855-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | ELI LILLY AND COMPANY (US) | 2009-10-08 | — | — | WO | disclosed |