Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11104154 | 0.85 | EGFR (0.53) | MAPK1HTTPDE5AEGFRCDK1 | |
| SCHEMBL30983997 | 0.76 | HTT (0.55) | CDC7DBF4MAPK1RAF1HTT | |
| SCHEMBL8886913 | 0.75 | EGFR (0.72) | MAPK1RAF1HTTPDE5AEGFR | |
| SCHEMBL11103596 | 0.74 | HTT (0.55) | MAPK1HTTEGFRSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL8500107 | 0.74 | MAPK1 (0.72) | MAPK1RAF1HTTPDE5AEGFR | |
| SCHEMBL5470044 | 0.74 | ALDH1A1 (0.49) | CDC7DBF4SRCSMN1; SMN2LMNA | |
| SCHEMBL639807 | 0.73 | CDC7 (0.67) | CDC7DBF4MAPK1RAF1HTT | |
| SCHEMBL22872882 | 0.73 | EGFR (0.71) | CDC7DBF4MAPK1RAF1HTT | |
| SCHEMBL5809191 | 0.73 | ENPP1 (0.41) | CDC7DBF4MAPK1RAF1HTT | |
| SCHEMBL11106892 | 0.72 | SMN1; SMN2 (0.56) | MAPK1HTTPDE5ACDK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435402-A | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY, LIMITED (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0057440-A1 | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-08-11 | — | — | EP | disclosed |