Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LIPA | P38571 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272608 | 0.96 | ALDH1A1 (0.52) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL8793041 | 0.80 | TDP1 (0.56) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL10993216 | 0.80 | TDP1 (0.56) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL3796363 | 0.80 | TDP1 (0.56) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL1588408 | 0.77 | SMN1; SMN2 (0.78) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL22260724 | 0.77 | SMN1; SMN2 (0.78) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL7591866 | 0.77 | SMN1; SMN2 (0.78) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL4434481 | 0.77 | SMN1; SMN2 (0.78) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL1588404 | 0.77 | SMN1; SMN2 (0.78) | SMN1; SMN2BLMALDH1A1MAPTKDM4E | |
| SCHEMBL25063558 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2BLMALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4195085-A | Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate | MERCK & CO., INC. (US) | 1980-03-25 | — | — | US | claimed |
| EP-0105996-A1 | Ophthalmic compositions for treating elevated intraocular pressure | MERCK & CO. INC. (US) | 1984-04-25 | — | — | EP | disclosed |
| US-4195085-A | Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate | MERCK & CO., INC. (US) | 1980-03-25 | — | — | US | disclosed |
| US-4195085-A | Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate | MERCK & CO., INC. (US) | 1980-03-25 | — | — | US | disclosed |