Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 4/20 | 0.36 |
| ▸ | IDH2 | P48735 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317402 | 0.84 | P2RX7 (0.43) | P2RX7MBOAT4NOTUMADRB1IDH1 | |
| SCHEMBL7035568 | 0.81 | P2RX7 (0.41) | P2RX7MBOAT4NOTUMADRB1IDH1 | |
| SCHEMBL8190474 | 0.81 | KCNH2 (0.46) | P2RX7MBOAT4NOTUMADRB1IDH1 | |
| SCHEMBL25402832 | 0.81 | P2RX7 (0.45) | P2RX7MBOAT4NOTUMADRB1IDH1 | |
| SCHEMBL27983844 | 0.81 | P2RX7 (0.41) | P2RX7MBOAT4NOTUMADRB1IDH1 | |
| SCHEMBL23343864 | 0.81 | P2RX7 (0.45) | P2RX7MBOAT4NOTUMADRB1IDH1 | |
| SCHEMBL7037038 | 0.78 | KCNH2 (0.43) | P2RX7MBOAT4NOTUMADRB1IDH2 | |
| SCHEMBL18494297 | 0.78 | KCNH2 (0.56) | P2RX7MBOAT4ADRB1IDH1IDH2 | |
| SCHEMBL28914699 | 0.78 | KCNH2 (0.66) | P2RX7MBOAT4NOTUMKCNH2NR3C1 | |
| SCHEMBL14834464 | 0.78 | P2RX7 (0.39) | P2RX7MBOAT4NOTUMADRB1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |