Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 3/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL141481 | 0.91 | DHODH (0.48) | DHODHALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL110884 | 0.83 | PLA2G2A (0.59) | DHODHALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL15976010 | 0.82 | DHODH (0.41) | DHODHALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL140353 | 0.78 | PLA2G2A (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL109071 | 0.75 | CA12 (0.42) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4602311 | 0.74 | KDM4E (0.62) | DHODHALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29707061 | 0.74 | DHODH (0.47) | DHODHALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22981957 | 0.74 | DHODH (0.47) | DHODHALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15976449 | 0.74 | DHODH (0.41) | DHODHALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1926175 | 0.71 | MAPT (0.55) | DHODHNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815840-B2 | Carbazole and carboline kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-26 | — | — | US | disclosed |
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | JAK2, JAK1, JAK3 | DHODH 3348/4885ALDH1A1 1464/4885NPC1 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.