SCHEMBL11115355

SCHEMBL11115355

CC(O)[C@H]1C(=O)N2C(C(=O)OCc3ccccc3)=C([S+]([O-])c3ccccc3)C[C@@H]12

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 14/20 0.50
GPBAR1 Q8TDU6 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11109337 1.00 ELANE (0.50) ELANEGPBAR1
SCHEMBL11128916 0.85 ELANE (0.41) ELANEGPBAR1
SCHEMBL11590192 0.85 KDM4E (0.43) ELANE
SCHEMBL11107828 0.85 KDM4E (0.43) ELANE
Ethyl Acetate SCHEMBL11262607 0.82 KDM4E (0.39) ELANE
SCHEMBL10568991 0.82 ELANE (0.55) ELANEGPBAR1
SCHEMBL11276416 0.82 ELANE (0.55) ELANEGPBAR1
SCHEMBL11277393 0.82 ELANE (0.55) ELANEGPBAR1
SCHEMBL11042688 0.82 ELANE (0.55) ELANEGPBAR1
SCHEMBL11571355 0.82 ELANE (0.41) ELANEGPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0002564-B1 DERIVATIVES OF 7-OXO-1-AZABICYCLO(3.2.0)-HEPT-2-ENE-2-CARBOXYLIC ACID, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES BEECHAM GROUP PLC (GB) 1984-06-20 EP disclosed
US-4347181-A Intermediates for producing bicyclic β-lactam-antibiotics BEECHAM GROUP LIMITED (GB) 1982-08-31 US disclosed
US-4289696-A BETA-LACTAMASE INHIBITORY AGENTS WHICH ENHANCE ACTIVITY OF A PENICICILLIN OR CEPHALOSPORIN BEECHAM GROUP LIMITED (GB) 1981-09-15 US disclosed
US-4223038-A THIENAMYCINS BEECHAM GROUP LIMITED (GB) 1980-09-16 US disclosed
EP-0002564-A1 Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates BEECHAM GROUP PLC (GB) 1979-06-27 EP disclosed