Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117748 | 0.88 | KMT2A (0.61) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11118417 | 0.88 | CYP1A2 (0.55) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11119837 | 0.85 | JAK2 (0.44) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11117718 | 0.84 | JAK2 (0.43) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11114055 | 0.82 | KMT2A (0.49) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11121938 | 0.80 | KMT2A (0.55) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11118397 | 0.79 | AURKB (0.70) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11122630 | 0.79 | JAK2 (0.58) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL4122238 | 0.78 | LMNA (0.67) | MEN1KMT2ALMNACYP1A2CA12 | |
| SCHEMBL11116974 | 0.78 | MEN1 (0.52) | MEN1KMT2AJAK2NTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |