Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | MET | P08581 | 6/20 | 0.51 |
| ▸ | FYN | P06241 | 4/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808285 | 0.83 | KMT2A (0.58) | KDM4EHSD17B10BRD4 | |
| SCHEMBL26101880 | 0.81 | FYN (0.48) | KDM4EHSD17B10FYNBRD4 | |
| SCHEMBL2646931 | 0.80 | KDM4E (0.67) | KDM4EHSD17B10METFYNBRD4 | |
| SCHEMBL11489169 | 0.79 | KDM4E (0.65) | KDM4EHSD17B10BRD4 | |
| SCHEMBL4506913 | 0.79 | KDM4E (0.65) | KDM4EHSD17B10METFYNBRD4 | |
| SCHEMBL10806414 | 0.79 | KDM4E (0.65) | KDM4EHSD17B10METFYNBRD4 | |
| Hydrochloric Acid SCHEMBL11199042 | 0.77 | KDM4E (0.63) | KDM4EHSD17B10METFYNBRD4 | |
| SCHEMBL26482633 | 0.76 | POLB (0.57) | MET | |
| SCHEMBL2422242 | 0.75 | MET (0.66) | KDM4EHSD17B10METFYN | |
| SCHEMBL11472651 | 0.75 | MET (0.62) | KDM4EHSD17B10MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0121490-A1 | Substituted 6-aryl-1,2,4-triazolo[4,3-b]pyridazines, their preparation and use | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-10-10 | — | — | EP | disclosed |