Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30785536 | 0.96 | IDO1 (0.46) | IDO1KDM4EALDH1A1ATMSLC6A2 | |
| Bromide SCHEMBL376589 | 0.96 | IDO1 (0.46) | IDO1KDM4EALDH1A1ATMSLC6A2 | |
| Bromide SCHEMBL2291771 | 0.80 | IDO1 (0.46) | IDO1SLC6A4PPARGPPARAMAOB | |
| Hydrochloric Acid SCHEMBL9292231 | 0.80 | HIF1A (0.55) | ALDH1A1SLC6A2SLC6A4HIF1AKMT2A | |
| Bromide SCHEMBL9262610 | 0.78 | POLQ (0.46) | ALDH1A1POLQ | |
| Bromide SCHEMBL22615969 | 0.78 | IDO1 (0.47) | IDO1SLC6A2SLC6A4PPARGHIF1A | |
| Bromide SCHEMBL4175836 | 0.78 | HIF1A (0.40) | IDO1KDM4EALDH1A1ATMSLC6A2 | |
| Hydrochloric Acid SCHEMBL9235165 | 0.77 | CXCR4 (0.41) | KDM4ESLC6A2SLC6A4HIF1AEPHX2 | |
| Bromide SCHEMBL20768319 | 0.77 | KDM1A (0.35) | IDO1HIF1APOLQEPHX2SNCA | |
| Bromide SCHEMBL16268042 | 0.77 | POLQ (0.41) | KDM4EALDH1A1ATMSLC6A4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025159-B1 | USE OF STYRENE POLYMERS FOR THE PREPARATION OF OPTICAL SYSTEM | BAYER AG (DE) | 1984-05-09 | — | — | EP | disclosed |
| US-4420225-A | Lens of a homo- or copolymer of a fluorine containing styrene polymer | BAYER AKTIENGESELLSCHAFT (DE) | 1983-12-13 | — | — | US | disclosed |
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0025159-A2 | Use of styrene polymers for the preparation of optical system | BAYER AG (DE) | 1981-03-18 | — | — | EP | disclosed |