Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11120728 | 0.91 | JAK2 (0.45) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11117615 | 0.86 | JAK2 (0.45) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11117616 | 0.86 | JAK2 (0.45) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11123381 | 0.84 | KDR (0.51) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11116880 | 0.84 | LMNA (0.54) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11116431 | 0.81 | SMN1; SMN2 (0.51) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11118133 | 0.81 | KDR (0.49) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11131789 | 0.81 | JAK2 (0.47) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11119383 | 0.81 | JAK2 (0.49) | JAK2NTRK1RETPDGFRBCDK8 | |
| SCHEMBL11120040 | 0.81 | LMNA (0.50) | JAK2NTRK1RETPDGFRBCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |