Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Butane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL22773725 | 0.86 | — | — | |
| Butane SCHEMBL9815469 | 0.86 | — | — | |
| Butane SCHEMBL20917800 | 0.86 | — | — | |
| Butane SCHEMBL3787272 | 0.86 | — | — | |
| Butane SCHEMBL8628663 | 0.84 | TSHR (0.50) | TSHRLMNATHRBSLC22A1ALDH1A1 | |
| Butane SCHEMBL9292387 | 0.84 | TSHR (0.50) | TSHRLMNATHRBSLC22A1ALDH1A1 | |
| Butane SCHEMBL3593 | 0.84 | — | — | |
| Butane SCHEMBL1734106 | 0.84 | — | — | |
| Butane SCHEMBL2470336 | 0.84 | TSHR (0.50) | TSHRLMNATHRBSLC22A1ALDH1A1 | |
| Butane SCHEMBL1617316 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483785-A | DISSOLVING PENTAFLUORIDE SALT, ADDING TITANIUM DIOXIDE, SLURRYING, AND SINTERING | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 1984-11-20 | — | — | US | disclosed |
| US-4160069-A | Electrically conductive and corrosion resistant current collector and/or container | UNIVERSITY OF UTAH (US) | 1979-07-03 | — | — | US | disclosed |