Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.65 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5952485 | 0.81 | ACHE (0.69) | ACHEKDM4EALDH1A1HTT | |
| SCHEMBL11112654 | 0.80 | GRM2 (0.51) | ACHEATMCA1CA2ALDH1A1 | |
| SCHEMBL11115689 | 0.80 | GRM2 (0.43) | ACHEKDM4EALDH1A1 | |
| SCHEMBL26495157 | 0.80 | ACHE (0.43) | ACHEATMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL11027295 | 0.79 | GRM2 (0.50) | ACHEKDM4EALDH1A1CYP3A4TSHR | |
| SCHEMBL11603610 | 0.79 | HSD17B10 (0.54) | ACHECYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL11460630 | 0.78 | ACHE (0.45) | ACHECYP3A4TSHRHSD17B10HPGD | |
| SCHEMBL10660910 | 0.78 | GRM2 (0.44) | ACHE | |
| SCHEMBL10493480 | 0.78 | GRM2 (0.53) | ACHE | |
| SCHEMBL8536280 | 0.77 | KDM4E (0.47) | ACHEKDM4EALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0027948-B1 | TETRAHYDRO-FLUORENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | MERCK & CO. INC. (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4356314-A | [5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives | MERCK & CO., INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4356313-A | [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts | MERCK & CO., INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4337354-A | BRAIN AND SPINAL CHORD DAMAGE | MERCK & CO., INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4317922-A | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives | MERCK & CO., INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4316043-A | ANTIEDEMIC AGENTS | MERCK & CO., INC. (US) | 1982-02-16 | — | — | US | disclosed |
| EP-0027948-A1 | Tetrahydro-fluorene compounds, processes for their preparation and pharmaceutical compositions thereof | MERCK & CO. INC. (US) | 1981-05-06 | — | — | EP | disclosed |
| US-4182764-A | DIURETIC, URICOSURIC | MERCK & CO., INC. (US) | 1980-01-08 | — | — | US | disclosed |
| US-4177285-A | DIURETICS, HYPOTENSIVES | MERCK & CO., INC. (US) | 1979-12-04 | — | — | US | disclosed |
| US-4096267-A | (1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof | MERCK & CO., INC. (US) | 1978-06-20 | — | — | US | disclosed |
| US-4085219-A | DIURETICS, SALURETICS, URICOSURIC AGENTS | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |
| US-4081554-A | DIURETICS, SALURETICS, URICOSURICS | MERCK & CO., INC. (US) | 1978-03-28 | — | — | US | disclosed |
| US-4012524-A | DIURETICS, SALURETICS, HYPOURICEMICS, HYPOTENSIVES, ANTIEDEMICS | MERCK & CO., INC. (US) | 1977-03-15 | — | — | US | disclosed |
| US-3984552-A | 6-Oxo-7-substituted and 7,7-disubstituted-6H-indeno-[5,4-b]furan (and thiophene) carboxylic acids | MERCK & CO., INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3984465-A | DIURETIC, SALURETIC AND URICOSURIC | MERCK & CO., INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3974212-A | DIURETIC, SALURETIC, URICOSURIC | MERCK & CO., INC. (US) | 1976-08-10 | — | — | US | disclosed |